Regioselective N-Alkylation in 5-Fluorouracil.
نویسندگان
چکیده
منابع مشابه
Regioselective N-alkylation of 2-aminobenzothiazoles with benzylic alcohols.
The preparation of 2-(N-alkylamino)benzothiazoles via regioselecive N-alkylation of 2-aminobenzothiazoles has been accomplished by using benzylic alcohols as alkylating agents.
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Background: Epidermal nevus is a common skin hamartoma. Its definite treatment is difficult and in most cases the disease has recurrence. Objective: Evaluation of topical tretinoin 0.05% and 5 Fluorouracil (5FU) 5% in the treatment of epidermal nevus. Patients and Methods: Fifteen patients with epidermal nevus referred to skin clinic in Razi Hospital in Tehran whose diagnoses were confirm...
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Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
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The mechanochemical N-alkylation of imide derivatives was studied. Reactions under solvent-free conditions in a ball mill gave good yields and could be put in place of the classical solution conditions. The method is general and can be applied to various imides and alkyl halides. Phthalimides prepared under ball milling conditions were used in a mechanochemical Gabriel synthesis of amines by th...
متن کاملEffect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals
Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1979
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.33b-0515